SHARE ON: |
| |
| |
 |
 |
|
|
The emergence of coronavirus variants has provoked concern about their impact on the effectiveness of vaccines, and whether people who were previously infected might be more susceptible to reinfection.
But in welcome news, a new study on Tuesday showed that a key player in the immune response, called the killer T cell, remained mostly unaffected.
The finding is encouraging because although these white blood cells are not a first line defense against infection, they can help prevent severe disease.
Scientists at the National Institutes of Health and Johns Hopkins University analyzed blood samples from 30 people who had contracted and recovered from COVID-19 prior to the emergence of variants.
They published their findings in Open Forum Infectious Diseases, an Oxford University Press journal.
The team wanted to know whether these cells, known by their technical name CD8+ T cells, could still recognize three variants of SARS-CoV-2: B.1.1.7, first found in Britain, B.1.351, identified in South Africa, and B.1.1.248, first seen in Brazil.
What makes each of these variants unique is the mutations they carry, especially in a region of the virus spike protein, structures that stud its surface and allow it to invade cells.
It has already been shown that mutations to this region of the spike protein make some variants less recognizable to neutralizing antibodies -- infection fighting proteins produced by the immune systems B cells.
This seems to be particularly true, for instance, of B.1.351, according to research on the impact of current generation COVID-19 vaccines.
Neutralizing antibodies are custom-made to fit an antigen, or a specific structure of a pathogen.
In the case of the coronavirus, this is the spike protein, which the antibodies bind to, preventing the virus from infecting cells.
Killer T cells, on the other hand, look for telltale signs of cells that have already been infected with pathogens they have previously encountered, and then kill those cells.
In the new study, the researchers found that the killer T cell responses remained largely intact and could recognize virtually all mutations in the variants studied.
The researchers noted that larger studies are needed to confirm the results, but said that it nevertheless demonstrated that killer T cells are less susceptible to mutations in the coronavirus than neutralizing antibodies are.
Antibodies are still important to prevent infection in the first place -- and the reduced efficacy of vaccines to the variants seems to be evidence of this.
But a killer T cell response that kicks in later and aids in clearing off the disease, helps explain why the vaccines seem to be able to prevent severe disease and hospitalization, even though their efficacy at stopping infection by variants is reduced.
|
 |
|
 |
|
 |
|
 |
6 am |
| 17 ℃ |
| SCATTERED CLOUDS |
WIND: NE 17 KM/H
GUSTING TO 33 KM/H |
|
|
 |
7 am |
| 17 ℃ |
| MODERATE RAIN |
WIND: NE 20 KM/H
GUSTING TO 38 KM/H |
|
|
|
8 am |
| 17 ℃ |
| HEAVY INTENSITY RAIN |
WIND: NE 21 KM/H
GUSTING TO 32 KM/H |
|
|
|
9 am |
| 18 ℃ |
| LIGHT RAIN |
WIND: ENE 22 KM/H
GUSTING TO 29 KM/H |
|
|
|
10 am |
| 19 ℃ |
| LIGHT RAIN |
WIND: ENE 28 KM/H
GUSTING TO 35 KM/H |
|
|
|
11 am |
| 21 ℃ |
| LIGHT RAIN |
WIND: E 19 KM/H
GUSTING TO 26 KM/H |
|
|
|
12 pm |
| 22 ℃ |
| LIGHT RAIN |
WIND: NE 23 KM/H
GUSTING TO 31 KM/H |
|
|
 |
1 pm |
| 23 ℃ |
| OVERCAST CLOUDS |
WIND: ENE 23 KM/H
GUSTING TO 31 KM/H |
|
|
|
|
TODAY |
HIGH OF 25 ℃
LOW OF 16 ℃ |
| HEAVY INTENSITY RAIN |
|
|
|
MONDAY |
HIGH OF 16 ℃
LOW OF 14 ℃ |
| MODERATE RAIN |
|
|
|
TUESDAY |
HIGH OF 17 ℃
LOW OF 10 ℃ |
| MODERATE RAIN |
|
|
|
WEDNESDAY |
HIGH OF 23 ℃
LOW OF 12 ℃ |
| LIGHT RAIN |
|
|
|
THURSDAY |
HIGH OF 27 ℃
LOW OF 15 ℃ |
| OVERCAST CLOUDS |
|
|
|
FRIDAY |
HIGH OF 14 ℃
LOW OF 10 ℃ |
| LIGHT RAIN |
|
|
|
SATURDAY |
HIGH OF 14 ℃
LOW OF 8 ℃ |
| BROKEN CLOUDS |
|
|
|
SUNDAY |
HIGH OF 19 ℃
LOW OF 10 ℃ |
| BROKEN CLOUDS |
|
|
|
|
|
 |
 |
|
| Buy One Get One 50% Off On BURST Oral Probiotics! |
| |
| Buy one Oral Probiotic, get a second for 50% off. Mix and match allowed. Adult Oral Probiotics includes one packet of Teeth Whitening Breath Strips plus one refillable Floss... |
| |
| Kids Oral Probiotics includes one packet of Kids Flossables. Mix and match allowed. |
|
 |
|
 |
|
|
 |
 |
THE CULT
FIREWOMAN
06:03 AM |
|
 |
THE GLORIOUS SONS
THE CONTENDER
06:00 AM |
|
 |
CREED
ONE LAST BREATH
05:56 AM |
|
 |
JONATHAN YOUNG
WHAT IT SOUNDS LIKE
05:52 AM |
|
 |
POPPY
RIBS
05:48 AM |
|
 |
THE FUNERAL PORTRAIT
BLOOD MOTHER
05:43 AM |
|
 |
STARSET
SHATTERED DREAMS
05:38 AM |
|
 |
NOTHING MORE
GO TO WAR
05:34 AM |
|
 |
EMBERWAVE
HOW TO TAKE FLIGHT
05:29 AM |
|
 |
KEITH WALLEN
INFINITY
05:26 AM |
|
 
 |
